Mucosal Gene Expression of Cell Adhesion Molecules, Chemokines, and Chemokine Receptors in Patients With Inflammatory Bowel Disease Before and After Infliximab Treatment

@article{Arijs2011MucosalGE,
  title={Mucosal Gene Expression of Cell Adhesion Molecules, Chemokines, and Chemokine Receptors in Patients With Inflammatory Bowel Disease Before and After Infliximab Treatment},
  author={Ingrid Arijs and Gert de Hertogh and Kathleen Machiels and Kristel Van Steen and Katleen Lemaire and Anica Schraenen and Leentje Van Lommel and Roel Quintens and Gert van Assche and S{\'e}verine Vermeire and Frans Schuit and P. R. Rutgeerts},
  journal={The American Journal of Gastroenterology},
  year={2011},
  volume={106},
  pages={748-761}
}
OBJECTIVES:Inflammatory bowel disease (IBD) is characterized by a continuous influx of leukocytes into the gut wall. This migration is regulated by cell adhesion molecules (CAMs), and selective antimigration therapies have been developed. This study investigated the effect of infliximab therapy on the mucosal gene expression of CAMs in IBD.METHODS:Mucosal gene expression of 69 leukocyte/endothelial CAMs and E-cadherin was investigated in 61 IBD patients before and after first infliximab… CONTINUE READING
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