Mucoid conversion of Pseudomonas aeruginosa by hydrogen peroxide: a mechanism for virulence activation in the cystic fibrosis lung.

@article{Mathee1999MucoidCO,
  title={Mucoid conversion of Pseudomonas aeruginosa by hydrogen peroxide: a mechanism for virulence activation in the cystic fibrosis lung.},
  author={K. Mathee and O. Ciofu and C. Sternberg and P. W. Lindum and J. Campbell and P. Jensen and A. Johnsen and M. Givskov and D. Ohman and S. Molin and N. H{\o}iby and A. Kharazmi},
  journal={Microbiology},
  year={1999},
  volume={145 ( Pt 6)},
  pages={
          1349-57
        }
}
The leading cause of mortality in patients with cystic fibrosis (CF) is respiratory failure due in large part to chronic lung infection with Pseudomonas aeruginosa strains that undergo mucoid conversion, display a biofilm mode of growth in vivo and resist the infiltration of polymorphonuclear leukocytes (PMNs), which release free oxygen radicals such as H2O2. The mucoid phenotype among the strains infecting CF patients indicates overproduction of a linear polysaccharide called alginate. To… Expand
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Pseudomonas aeruginosa alginate is refractory to Th1 immune response and impedes host immune clearance in a mouse model of acute lung infection.
Polymorphonuclear Leukocytes or Hydrogen Peroxide Enhance Biofilm Development of Mucoid Pseudomonas aeruginosa
Adaptation of Pseudomonas aeruginosa during persistence in the cystic fibrosis lung.
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