Mucociliary clearance – a critical upper airway host defense mechanism and methods of assessment

@article{Antunes2007MucociliaryC,
  title={Mucociliary clearance – a critical upper airway host defense mechanism and methods of assessment},
  author={Marcelo B. Antunes and Noam A Cohen},
  journal={Current Opinion in Allergy and Clinical Immunology},
  year={2007},
  volume={7},
  pages={5–10}
}
Purpose of review Mucociliary clearance is a critical host defense mechanism of the airways. Effective mucociliary clearance requires appropriate mucus production and coordinated ciliary activity. The important role of these two components is best demonstrated in disorders such as primary ciliary dyskinesia and cystic fibrosis, both of which lead to lifelong recurrent respiratory tract infections. We review the methods used to analyze mucociliary clearance. Recent findings Utilization of… Expand
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References

SHOWING 1-10 OF 89 REFERENCES
Regulation of mucociliary clearance in health and disease.
TLDR
The present paper reviews normal mucociliary clearance and the effects of diseases on this process and identifies diseases known to affect MCC, mostly negatively. Expand
Effects of guaifenesin on nasal mucociliary clearance and ciliary beat frequency in healthy volunteers.
TLDR
It is concluded that guaifenesin exerts no measurable effect on in vivo nasal mucociliary clearance or ex vivo nasal ciliary motility in healthy volunteers with previous sinus disease and there appears to be no relationship between nasal STT measured in vivo and CBF measured ex vivo. Expand
Regional Analysis of Sinonasal Ciliary Beat Frequency
TLDR
This study shows no regional differences in CBF within the sinonasal cavity, supporting previous work and validating analysis of inferior turbinate cilia. Expand
Regulation of normal and cystic fibrosis airway surface liquid volume by phasic shear stress.
TLDR
This review provides an update on the current understanding of how shear stress regulates ASL volume height in normal and cystic fibrosis (CF) airway epithelia through extracellular ATP- and adenosine (ADO)-mediated pathways that modulate ion transport and ASLVolume homeostasis. Expand
Soluble Mediators, Not Cilia, Determine Airway Surface Liquid Volume in Normal and Cystic Fibrosis Superficial Airway Epithelia
TLDR
It is found that maneuvers that mimic deposition of excess ASL onto the proximal airways, which occurs during mucociliary clearance and after glandular secretion, acutely stimulated Na+ absorption, suggesting that volume regulation was sensitive to changes in concentrations of soluble mediators in the ASL rather than alterations in ciliary beating. Expand
Coordinated clearance of periciliary liquid and mucus from airway surfaces.
TLDR
Mucus-dependent PCL transport was spatially uniform and exceeded the rate expected for pure frictional coupling with the overlying mucus layer; hence, ciliary mixing most likely accelerates the diffusion of momentum from mucus into the PCL. Expand
Possible mechanisms of reduction of nasal mucociliary clearance in chronic sinusitis.
TLDR
The results suggest that factors other than the rheological properties of nasal mucus control nasal mucociliary clearance in patients with chronic sinusitis are likely to be factors behind the observed differences in MTR on frog palate. Expand
Mucociliary transport determined by in vivo microdialysis in the airways of normal and CF mice.
TLDR
A versatile, simple in vivo method to measure mucociliary transport (MCT) in both upper and lower airways of mice and larger animals is developed. Expand
The role of mucus in transport by cilia.
TLDR
It was shown that the role of mucus in the mucociliary system of respiratory epithelium is highly specific and it is implied that in pathologic situations where clearance of excess mucus fails, the reason might be an alteration of the specific properties of mucu responsible for coupling with cilia. Expand
Altered Sinonasal Ciliary Dynamics in Chronic Rhinosinusitis
TLDR
Dynamic regulation of respiratory ciliary activity is critical for the respiratory epithelium to adapt to varying environmental situations, and the findings suggest that CRS patients have decreased sinonasal ciliary adaptation to environmental stimuli. Expand
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2
3
4
5
...