Mucoadhesive properties and interaction with P-glycoprotein (P-gp) of thiolated-chitosans and -glycol chitosans and corresponding parent polymers: a comparative study.

@article{Trapani2014MucoadhesivePA,
  title={Mucoadhesive properties and interaction with P-glycoprotein (P-gp) of thiolated-chitosans and -glycol chitosans and corresponding parent polymers: a comparative study.},
  author={Adriana Trapani and Claudio Palazzo and Marialessandra Contino and Maria Grazia Perrone and Nicola Cioffi and Nicoletta Ditaranto and Nicola A. Colabufo and Massimo Conese and Giuseppe Trapani and Giovanni Puglisi},
  journal={Biomacromolecules},
  year={2014},
  volume={15 3},
  pages={882-93}
}
The aim of the present work was to compare the mucoadhesive and efflux pump P-glycoprotein (P-gp) interacting properties of chitosan (CS)- and glycolchitosan (GCS)-based thiomers and corresponding unmodified parent polymers. For this purpose, the glycol chitosan-N-acetyl-cysteine (GCS-NAC) and glycol chitosan-glutathione (GCS-GSH) thiomers were prepared under simple and mild conditions. Their mucoadhesive characteristics were studied by turbidimetric and zeta potential measurements. The P-gp… CONTINUE READING