Mucoadhesive microspheres containing gentamicin sulfate for nasal administration: preparation and in vitro characterization.

@article{Hasiek2003MucoadhesiveMC,
  title={Mucoadhesive microspheres containing gentamicin sulfate for nasal administration: preparation and in vitro characterization.},
  author={Canan Hasçiçek and Nurşin G{\"o}n{\"u}l and Nevin Erk},
  journal={Farmaco},
  year={2003},
  volume={58 1},
  pages={11-6}
}
In this study, suitable microsphere formulations were designed in order to provide the absorption of a high polar drug through nasal mucosa. For this purpose, gentamicin sulfate (GS) was chosen as a model drug and used at different drug/polymer ratios in the microsphere formulations. The microspheres were prepared by spray drying technique. Hydroxypropyl methylcellulose was used as a mucoadhesive polymer in the formulations to increase the residence time of the microspheres on the mucosa… CONTINUE READING

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