Mucoadhesion of polystyrene nanoparticles having surface hydrophilic polymeric chains in the gastrointestinal tract.

Abstract

The mucoadhesion of polystyrene nanoparticles having surface hydrophilic polymeric chains in the gastrointestinal (GI) tract was investigated in rats. Radiolabeled nanoparticles were synthesized by adding hydrophobic 3-(trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine in the final process of nanoparticle preparation. The radioiodonated diazirine seemed to… (More)

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Cite this paper

@article{Sakuma1999MucoadhesionOP, title={Mucoadhesion of polystyrene nanoparticles having surface hydrophilic polymeric chains in the gastrointestinal tract.}, author={Shinji Sakuma and Ryo Sudo and N. Suzuki and H. Kikuchi and Makoto Akashi and M. Hayashi}, journal={International journal of pharmaceutics}, year={1999}, volume={177 2}, pages={161-72} }