Mucins as key molecules for the classification of intestinal metaplasia of the stomach

@article{Silva2001MucinsAK,
  title={Mucins as key molecules for the classification of intestinal metaplasia of the stomach},
  author={Elisabete A. Silva and Ana K. Teixeira and Leonor David and F{\'a}tima Carneiro and Celso A Reis and Joana Sobrinho-Sim{\~o}es and Jacinta Serpa and Enno Veerman and Jan G. M. Bolscher and Manuel Sobrinho-Sim{\~o}es},
  journal={Virchows Archiv},
  year={2001},
  volume={440},
  pages={311-317}
}
Mucins and mucin-associated carbohydrates have a distinct expression pattern that can be modified under pathological conditions. Normal gastric mucosa expresses MUC1 and MUC5AC in foveolar epithelium and MUC6 in the glands. Lewis type-1 chain antigens (Lea and Leb) are expressed in foveolar epithelium, whereas Lewis type-2 chain antigens (Lex and Ley) are expressed in the glands. In this study we used monoclonal antibodies to evaluate the pattern of mucins and Lewis type-1 carbohydrates in… CONTINUE READING