Mucins and mucosal protection in the gastrointestinal tract: new prospects for mucins in the pathology of gastrointestinal disease.

@article{Corfield2000MucinsAM,
  title={Mucins and mucosal protection in the gastrointestinal tract: new prospects for mucins in the pathology of gastrointestinal disease.},
  author={Anthony P Corfield and Neil Myerscough and Robert Longman and P. J. Sylvester and S. Benjamin Arul and Massimo Pignatelli},
  journal={Gut},
  year={2000},
  volume={47 4},
  pages={589-94}
}
The luminal surface of the gastrointestinal tract is covered by a viscoelastic mucous gel layer that acts as a protective barrier against the harsh luminal environment. The structural characteristics of this barrier are primary indicators of its physiological function and changes to its composition have long been identified in gastrointestinal pathologies. During the past decade significant improvements in analytical techniques coupled with detailed knowledge of the genes coding for the mucin… CONTINUE READING
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