Mucins (MUC1 and MUC3) of gastrointestinal and breast epithelia reveal different and heterogeneous tumor-associated aberrations in glycosylation.

@article{Cao1997MucinsA,
  title={Mucins (MUC1 and MUC3) of gastrointestinal and breast epithelia reveal different and heterogeneous tumor-associated aberrations in glycosylation.},
  author={Yanran Cao and Dietmar Blohm and B. Michael Ghadimi and Peter Stosiek and Pei Xiang Xing and Uwe Karsten},
  journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  year={1997},
  volume={45 11},
  pages={
          1547-57
        }
}
In a comprehensive study, we examined the expression of the membrane and secretory mucins MUC1 and MUC3, respectively, in normal and neoplastic gastrointestinal and breast epithelia before and after specific alterations of their glycan structures by neuraminidase, alpha-fucosidase, or carbohydrate-specific periodate oxidation. MUC1 mRNA was also identified in normal colorectal tissues by in situ hybridization. The data revealed that normal colorectal epithelia express both MUC1 mRNA and protein… CONTINUE READING
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