Mucin immunohistochemistry in the diagnosis and mapping of extramammary Paget's disease

@inproceedings{Smith2008MucinII,
  title={Mucin immunohistochemistry in the diagnosis and mapping of extramammary Paget's disease},
  author={Russell F. Smith and Bernard H Stern and Albert A. Smith},
  booktitle={Journal of cellular and molecular medicine},
  year={2008}
}
Extramammary Paget's disease (EMPD) is a rare skin cancer of the genital region in which cancer cells with enlarged nuclei and pale cytoplasm are scattered singly in the affected epidermis. These cancer cells, called Paget cells, contain mucin, which is never found in normal epidermis. The oligosaccharide side chains of Paget cell mucin end with sialic acid. Sialic acid is easily detected by zirconyl haematoxylin or alcian blue. The other sugars in the oligosaccharide chains can be detected by… CONTINUE READING
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