Mucin gene (MUC 2 and MUC 5AC) upregulation by Gram-positive and Gram-negative bacteria.

@article{Dohrman1998MucinG,
  title={Mucin gene (MUC 2 and MUC 5AC) upregulation by Gram-positive and Gram-negative bacteria.},
  author={Austin F. Dohrman and Sachiko Miyata and Marianne Gallup and Jiang Li and Catherine Chapelin and Andr{\'e} Coste and Estelle Escudier and Jay A. Nadel and Carol B. Basbaum},
  journal={Biochimica et biophysica acta},
  year={1998},
  volume={1406 3},
  pages={251-9}
}
Bacterial infection of the lung is associated with mucin overproduction. In partial explanation of this phenomenon, we recently reported that supernatant from the Gram-negative organism Pseudomonas (P.) aeruginosa contained an activity that upregulated transcription of the MUC 2 mucin gene [J.-D. Li, A. Dohrman, M. Gallup, S. Miyata, J. Gum, Y. Kim, J. Nadel, A. Prince, C. Basbaum, Transcriptional activation of mucin by P. aeruginosa lipopolysaccharide in the pathogenesis of cystic fibrosis… CONTINUE READING

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