Mucin-depleted foci show strong activation of inflammatory markers in 1,2-dimethylhydrazine-induced carcinogenesis and are promoted by the inflammatory agent sodium dextran sulfate.

@article{Femia2009MucindepletedFS,
  title={Mucin-depleted foci show strong activation of inflammatory markers in 1,2-dimethylhydrazine-induced carcinogenesis and are promoted by the inflammatory agent sodium dextran sulfate.},
  author={Angelo Pietro Femia and Piero Dolara and Cristina Luceri and Maddalena Salvadori and Giovanna Caderni},
  journal={International journal of cancer},
  year={2009},
  volume={125 3},
  pages={541-7}
}
Mucin-depleted foci (MDF), formed by dysplastic crypts devoid of mucins, have been identified in the colon of carcinogen-treated rodents and in humans at high risk for colon cancer. The lack of the protective layer of mucus may cause inflammation which has been linked to colon carcinogenesis, therefore, the expression of markers such as cyclooxygenase-2… CONTINUE READING