Mucin Gene Deficiency in Mice Impairs Host Resistance to an Enteric Parasitic Infection

@inproceedings{Hasnain2010MucinGD,
  title={Mucin Gene Deficiency in Mice Impairs Host Resistance to an Enteric Parasitic Infection},
  author={Sumaira Z Hasnain and Huaqing Wang and Jean–Eric Ghia and Nihal Haq and Yikang Deng and Anna Velcich and Richard K Grencis and David E. Thornton and Waliul I Khan},
  booktitle={Gastroenterology},
  year={2010}
}
BACKGROUND & AIMS Hyperplasia of mucin-secreting intestinal goblet cells accompanies a number of enteric infections, including infections by nematode parasites. Nevertheless, the precise role of mucins in host defense in nematode infection is not known. We investigated the role of the mucin (Muc2) in worm expulsion and host immunity in a model of nematode infection. METHODS Resistant (BALB/c, C57BL/6), susceptible (AKR), and Muc2-deficient mouse strains were infected with the nematode… CONTINUE READING
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