Much more from the chicken's egg than breakfast – a wonderful model system

  title={Much more from the chicken's egg than breakfast – a wonderful model system},
  author={L. Wolpert},
  journal={Mechanisms of Development},
  • L. Wolpert
  • Published 2004
  • Biology, Medicine
  • Mechanisms of Development
The chick embryo has played a major role in the advance of our understanding of embryonic development. It has been particularly helpful in relation to amniotes like the mouse, for unlike the mouse in the early embryo the epiblast is beautifully flat, while in the mouse it is all curled up. Here I briefly describe some history and a few of the major achievements that came from the chick embryo. 

Topics from this paper

The chick; a great model system becomes even greater.
  • C. Stern
  • Biology, Medicine
  • Developmental cell
  • 2005
The chick embryo has a long and distinguished history as a major model system in developmental biology and has also contributed major concepts to immunology, genetics, virology, cancer, and cellExpand
Chicken embryo as a model for regenerative medicine.
  • C. Coleman
  • Biology, Medicine
  • Birth defects research. Part C, Embryo today : reviews
  • 2008
The chick offers a well-defined profile of intercellular and intracellular signaling pathways regulating the development of nearly every organ system in conjunction with great flexibility for chimeric and transgenic experiments. Expand
Rediscovering the chick embryo as a model to study retinal development
A general overview of the chick as a developmental model focusing more specifically on its application to the study of eye development and the state of the art of the techniques that have made gene gain- and loss-of-function studies in this model a reality is provided. Expand
From soil mechanics to chick development.
  • L. Wolpert
  • Biology, Medicine
  • The International journal of developmental biology
  • 2018
Here, I provide some recollections of my life, starting as a civil engineer in South Africa and how I gradually became interested in biology, particularly pattern formation. In retrospect, I thinkExpand
A Novel Fully Automated Incubation, Manipulation and Documentation System for the Avian Embryogenesis
An avian egg incubator with a modular lid system comprising a glass window with condensation prevention and a parallel access for manipulation and the influence of light exposure as well as turning speed and frequency on the embryo survival rate for optimized culture conditions is presented. Expand
Model organisms--A historical perspective.
The origins of a few model organisms are described, including E. coli, yeast, C. elegans, Drosophila, Xenopus, zebrafish, mouse, maize and Arabidopsis, which made them systems of choice for genome-wide studies. Expand
A new take on an old story: chick limb organ culture for skeletal niche development and regenerative medicine evaluation.
The evolution of the chick limb organ culture system is detailed and recent innovative developments and emerging techniques and technologies applied to these models that are aiding the understanding of skeletal developmental and regenerative medicine research and application are presented. Expand
Applications of Tol2 transposon-mediated gene transfer for stable integration and conditional expression of electroporated genes in chicken embryos
The electroporation technique using chickens has provided numerous novel insights into the understanding of early development in vertebrates, making the chicken a unique model animal. Expand
Artificial modeling of biologically inspired Left/Right Asymmetry for modeling developmental processes
A correlation of results obtained in the modeling and simulation of left/right asymmetry (LRA) development in artificial embryology systems with its role in the analysis and modeling of developmental processes, such as in biology is presented. Expand
Isolation, Characterization and Differentiation Potential of Chicken Spermatogonial Stem Cell Derived Embryoid Bodies
The most significant finding of this study is the differentiation potential of chicken SSCs into cardiomyocytes, which may have implication in developmental biology and regenerative medicine by using chicken as the most potential animal model. Expand


The Development of the Chick
  • B.
  • Nature
  • 1909
THE first feeling of an embryologist on examining this beautiful volume is of disappointment and regret that it treats solely of the development of so familiar an animal as the chick. The like styleExpand
The Principles of Development
This chapter discusses the development of the Drosophila body plan, as well as life cycles and experimental techniques, and the role of the nervous system in this development. Expand
The Elements of Experimental Embryology
THIS work is a rather surprising addition to the Cambridge Comparative Physiology series—surprising partly because it is twice as heavy as any of the earlier members of the series, and partly becauseExpand
Development of the eye of the chick embryo.
  • S. R. Hilfer
  • Chemistry, Medicine
  • Scanning electron microscopy
  • 1983
Experimental analysis of eye development has revealed an intimate relationship between invagination of the lens and optic cup, and the effects of inhibitory drugs suggest the involvement at least in part of a contractile mechanism during optic cup formation. Expand
Organisers and Genes
Genetical results have great practical value in the fields of agriculture, eugenics, and evolution, even if they are not applied to the study of development, but genetics will remain a somewhat isolated branch of biology until this is done. Expand
A History of Embryology
LOVERS of Tristram Shandy will remember that passage in which Sterne gives a cut of his ironic whip at the learned Catholic doctors of the Sorbonne, who in their zeal to save souls had given a veryExpand