Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection.

@article{Sluis2006Muc2deficientMS,
  title={Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection.},
  author={Maria E van der Sluis and Barbara E A de Koning and Adrianus C. J. M. de Bruijn and Anna Velcich and Jules P. P. Meijerink and Johannes B van Goudoever and Hans A. B{\"u}ller and Jan Dekker and Isabelle Van Seuningen and Ingrid B. Renes and Alexandra W. C. Einerhand},
  journal={Gastroenterology},
  year={2006},
  volume={131 1},
  pages={117-29}
}
BACKGROUND & AIMS Expression of mucin MUC2, the structural component of the colonic mucus layer, is lowered in inflammatory bowel disease. Our aim was to obtain insight in the role of Muc2 in epithelial protection. METHODS Muc2 knockout (Muc2(-/-)) and Muc2 heterozygous (Muc2(+/-)) mice were characterized and challenged by a colitis-inducing agent, dextran sulfate sodium (DSS). We monitored clinical symptoms, intestinal morphology, and differences in intestine-specific protein and messenger… CONTINUE READING
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