MuB protein allosterically activates strand transfer by the transposase of phage Mu.

@article{Baker1991MuBPA,
  title={MuB protein allosterically activates strand transfer by the transposase of phage Mu.},
  author={Tania A. Baker and Michiyo Mizuuchi and Kiyoshi Mizuuchi},
  journal={Cell},
  year={1991},
  volume={65 6},
  pages={1003-13}
}
The MuA and MuB proteins collaborate to mediate efficient transposition of the phage Mu genome into many DNA target sites. MuA (the transposase) carries out all the DNA cleavage and joining steps. MuB stimulates strand transfer by activating the MuA-donor DNA complex through direct protein-protein contact. The C-terminal domain of MuA is required for this MuA-MuB interaction. Activation of strand transfer occurs irrespective of whether MuB is bound to target DNA. When high levels of MuA… CONTINUE READING

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