Mu opioid receptors are in somatodendritic and axonal compartments of GABAergic neurons in rat hippocampal formation.

@article{Drake1999MuOR,
  title={Mu opioid receptors are in somatodendritic and axonal compartments of GABAergic neurons in rat hippocampal formation.},
  author={Carrie T Drake and Teresa A Milner},
  journal={Brain research},
  year={1999},
  volume={849 1-2},
  pages={203-15}
}
Activation of mu opioid receptors (MORs) has a net excitatory effect in the hippocampal formation through inhibition of gamma-amino butyric acid (GABA)-containing interneurons. To determine the precise subcellular targets of MOR agonists, immunoreactivity against MOR1 and GABA was examined in single sections of the hippocampal formation prepared for dual-labeling electron microscopy. In both the CA1 region of hippocampus and the dentate gyrus, MOR-like immunoreactivity (-li) was present in… CONTINUE READING