Mu opioid receptor A118G polymorphism in association with striatal opioid neuropeptide gene expression in heroin abusers.

@article{Drakenberg2006MuOR,
  title={Mu opioid receptor A118G polymorphism in association with striatal opioid neuropeptide gene expression in heroin abusers.},
  author={Katarina Drakenberg and Andrej Nikoshkov and Monika Cs Horv{\'a}th and Pernilla Fagergren and Anna Gharibyan and Kati S. Saarelainen and Sadia Rahman and Ingrid Nylander and Georgy Bakalkin and Jovan Rajs and {\'E}va Keller and Yasmin L Hurd},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 20},
  pages={
          7883-8
        }
}
Mu opioid receptors are critical for heroin dependence, and A118G SNP of the mu opioid receptor gene (OPRM1) has been linked with heroin abuse. In our population of European Caucasians (n = 118), approximately 90% of 118G allelic carriers were heroin users. Postmortem brain analyses showed the OPRM1 genotype associated with transcription, translation, and processing of the human striatal opioid neuropeptide system. Whereas down-regulation of preproenkephalin and preprodynorphin genes was… CONTINUE READING

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