Mu-opioid receptor (OPRM1) variation, oxytocin levels and maternal attachment in free-ranging rhesus macaques Macaca mulatta.

@article{Higham2011MuopioidR,
  title={Mu-opioid receptor (OPRM1) variation, oxytocin levels and maternal attachment in free-ranging rhesus macaques Macaca mulatta.},
  author={James P Higham and Christina S. Barr and Christy L. Hoffman and Tara M Mandalaywala and Karen J Parker and Dario Maestripieri Maestripieri},
  journal={Behavioral neuroscience},
  year={2011},
  volume={125 2},
  pages={131-6}
}
Understanding the genetic and neuroendocrine basis of the mother-infant bond is critical to understanding mammalian affiliation and attachment. Functionally similar nonsynonymous mu-opioid receptor (OPRM1) SNPs have arisen and been maintained in humans (A118G) and rhesus macaques Macaca mulatta (C77G). In rhesus macaques, variation in OPRM1 predicts individual differences in infant affiliation for mothers. Specifically, infants carrying the G allele show increased distress on separation from… CONTINUE READING

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Variation in the mu-opioid receptor gene (OPRM1) is associated with dispositional and neural sensitivity to social rejection

  • B. M. Way, S. E. Taylor, N. I. Eisenberg
  • Proceedings of the National Academy Sciences,
  • 2009
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