Mu-opioid Self-Administration vs Passive Administration in Heroin Abusers Produces Differential EEG Activation

Psychoactive drug self-administration (SA) produces different neurobiological effects than passive administration (PA) in non-human animals; however, such consequences have never been examined in human drug abusers. The present study compared electroencephalographic (EEG) activation produced by intravenous PA and SA of the mu-opioid fentanyl in eight heroin… CONTINUE READING