Mu opiate receptor gene dose effects on different morphine actions: evidence for differential in vivo mu receptor reserve.

@article{Sora2001MuOR,
  title={Mu opiate receptor gene dose effects on different morphine actions: evidence for differential in vivo mu receptor reserve.},
  author={Ichiro Sora and Greg Elmer and Masahiko Funada and Jeanne O. Pieper and Xiao-fang Li and F. Scott Hall and George R. Uhl},
  journal={Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology},
  year={2001},
  volume={25 1},
  pages={41-54}
}
Homozygous transgenic knockout mice without mu-opioid receptors lack morphine-induced antinociception, locomotion, tolerance, physical dependence, and reward. mu receptors thus appear to play central roles in these morphine actions. Different levels of mu receptor expression are found in different humans and in different animal strains. In vitro studies indicate that some morphine responses persist after inactivation of as many as 90% of the initial mu receptor complement, while others are… CONTINUE READING
28 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 28 extracted citations

Similar Papers

Loading similar papers…