Mu opiate receptor down-regulation by morphine and up-regulation by naloxone in SH-SY5Y human neuroblastoma cells.

@article{Zadina1993MuOR,
  title={Mu opiate receptor down-regulation by morphine and up-regulation by naloxone in SH-SY5Y human neuroblastoma cells.},
  author={James E. Zadina and Sulie L. Chang and Liyun Ge and Abba J. Kastin},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1993},
  volume={265 1},
  pages={254-62}
}
The human neuroblastoma cell line SH-SY5Y was used to demonstrate morphine-induced down-regulation and naloxone-induced up-regulation of opiate receptors in a mu receptor containing neuronally derived preparation capable of desensitization to morphine. Chronic exposure to morphine decreased the number but not the affinity of mu opiate receptors in SH-SY5Y cells. Differentiation of the cells with retinoic acid or with the phorbol agent TPA (12-O-tetradecanoyl-phorbol-13-acetate) increased the… CONTINUE READING
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