Mtx2 directs zebrafish morphogenetic movements during epiboly by regulating microfilament formation.

@article{Wilkins2008Mtx2DZ,
  title={Mtx2 directs zebrafish morphogenetic movements during epiboly by regulating microfilament formation.},
  author={Simon J Wilkins and Simon H S Yoong and Heather Verkade and Takamasa Mizoguchi and Sarah J. Plowman and John F Hancock and Yutaka Kikuchi and Joan K. Heath and Andrew C. Perkins},
  journal={Developmental biology},
  year={2008},
  volume={314 1},
  pages={12-22}
}
The homeobox transcription factor Mtx2 is essential for epiboly, the first morphogenetic movement of gastrulation in zebrafish. Morpholino knockdown of Mtx2 results in stalling of epiboly and lysis due to yolk rupture. However, the mechanism of Mtx2 action is unknown. The role of mtx2 is surprising as most mix/bix family genes are thought to have roles in mesendoderm specification. Using a transgenic sox17-promoter driven EGFP line, we show that Mtx2 is not required for endoderm specification… CONTINUE READING