Mts4, a non-ATPase subunit of the 26 S protease in fission yeast is essential for mitosis and interacts directly with the ATPase subunit Mts2.

@article{Wilkinson1997Mts4AN,
  title={Mts4, a non-ATPase subunit of the 26 S protease in fission yeast is essential for mitosis and interacts directly with the ATPase subunit Mts2.},
  author={Caroline R.M. Wilkinson and Mairi Wallace and Michael Seeger and Wolfgang Dubiel and Colin G. Gordon},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 41},
  pages={25768-77}
}
We have isolated a fission yeast gene, mts4(+), by complementation of a temperature-sensitive mutation and show that it encodes subunit 2 (S2) of the 19 S regulatory complex of the 26 S protease. mts4(+) is an essential gene, and we show that loss of this subunit causes cells to arrest in metaphase, illustrating the importance of S2 for mitosis. The Mts4 protein is 48% identical to S2 of the human 26 S protease, and the lethal phenotype of the null mts4 allele can be rescued by the human cDNA… CONTINUE READING

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