Mtr 10 p functions as a nuclear import receptor for the mRNA-binding protein Npl 3 p

@inproceedings{Senger2013Mtr1P,
  title={Mtr 10 p functions as a nuclear import receptor for the mRNA-binding protein Npl 3 p},
  author={Bruno Senger and George Simos and F. Ralf Bischoff and Alexandre V Podtelejnikov and Matthias Mann and Ed Hurt},
  year={2013}
}
MTR10, previously shown to be involved in mRNA export, was found in a synthetic lethal relationship with nucleoporin NUP85. Green fluorescent protein (GFP)-tagged Mtr10p localizes preferentially inside the nucleus, but a nuclear pore and cytoplasmic distribution is also evident. Purified Mtr10p forms a complex with Npl3p, an RNA-binding protein that shuttles in and out of the nucleus. In mtr10 mutants, nuclear uptake of Npl3p is strongly impaired at the restrictive temperature, while import of… CONTINUE READING

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