Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism.

@article{MacFarlane2009Mthfd1IA,
  title={Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism.},
  author={Amanda J MacFarlane and Cheryll A. Perry and Hussein H Girnary and Dacao Gao and Robert H. Allen and Sally P. Stabler and Barry Shane and Patrick J Stover},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 3},
  pages={1533-9}
}
Cytoplasmic folate-mediated one carbon (1C) metabolism functions to carry and activate single carbons for the de novo synthesis of purines, thymidylate, and for the remethylation of homocysteine to methionine. C1 tetrahydrofolate (THF) synthase, encoded by Mthfd1, is an entry point of 1Cs into folate metabolism through its formyl-THF synthetase (FTHFS) activity that catalyzes the ATP-dependent conversion of formate and THF to 10-formyl-THF. Disruption of FTHFS activity by the insertion of a… CONTINUE READING
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