MtDNA evidence for a genetic bottleneck in the early history of the Ashkenazi Jewish population

  title={MtDNA evidence for a genetic bottleneck in the early history of the Ashkenazi Jewish population},
  author={D. Behar and M. Hammer and Daniel Garrigan and R. Villems and B. Bonn{\'e}-Tamir and M. Richards and D. Gurwitz and D. Rosengarten and M. Kaplan and S. D. Pergola and L. Quintana-Murci and K. Skorecki},
  journal={European Journal of Human Genetics},
  • D. Behar, M. Hammer, +9 authors K. Skorecki
  • Published 2004
  • Biology, Medicine
  • European Journal of Human Genetics
  • The relative roles of natural selection and accentuated genetic drift as explanations for the high frequency of more than 20 Ashkenazi Jewish disease alleles remain controversial. To test for the effects of a maternal bottleneck on the Ashkenazi Jewish population, we performed an extensive analysis of mitochondrial DNA (mtDNA) hypervariable segment 1 (HVS-1) sequence and restriction site polymorphisms in 565 Ashkenazi Jews from different parts of Europe. These patterns of variation were… CONTINUE READING
    103 Citations
    Contrasting patterns of Y chromosome variation in Ashkenazi Jewish and host non-Jewish European populations
    • 96
    Mitochondrial DNA sequence variation in Jewish populations
    • 19
    Genetic differentiation of Jewish populations.
    • 36
    • Highly Influenced
    • PDF
    A substantial prehistoric European ancestry amongst Ashkenazi maternal lineages
    • 77
    • PDF
    Counting the Founders: The Matrilineal Genetic Ancestry of the Jewish Diaspora
    • 110
    • PDF


    Jewish and Middle Eastern non-Jewish populations share a common pool of Y-chromosome biallelic haplotypes.
    • 256
    • PDF
    The emerging tree of West Eurasian mtDNAs: a synthesis of control-region sequences and RFLPs.
    • 644
    • PDF
    Why hunter-gatherer populations do not show signs of pleistocene demographic expansions.
    • L. Excoffier, S. Schneider
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1999
    • 295
    • PDF
    Tracing European founder lineages in the Near Eastern mtDNA pool.
    • 950
    • PDF
    Extensive mitochondrial diversity within a single Amerindian tribe.
    • 457
    • PDF