MtDNA evidence for a genetic bottleneck in the early history of the Ashkenazi Jewish population
@article{Behar2004MtDNAEF, title={MtDNA evidence for a genetic bottleneck in the early history of the Ashkenazi Jewish population}, author={D. Behar and M. Hammer and Daniel Garrigan and R. Villems and B. Bonn{\'e}-Tamir and M. Richards and D. Gurwitz and D. Rosengarten and M. Kaplan and S. D. Pergola and L. Quintana-Murci and K. Skorecki}, journal={European Journal of Human Genetics}, year={2004}, volume={12}, pages={355-364} }
The relative roles of natural selection and accentuated genetic drift as explanations for the high frequency of more than 20 Ashkenazi Jewish disease alleles remain controversial. To test for the effects of a maternal bottleneck on the Ashkenazi Jewish population, we performed an extensive analysis of mitochondrial DNA (mtDNA) hypervariable segment 1 (HVS-1) sequence and restriction site polymorphisms in 565 Ashkenazi Jews from different parts of Europe. These patterns of variation were… CONTINUE READING
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