Msx2 and Twist cooperatively control the development of the neural crest-derived skeletogenic mesenchyme of the murine skull vault.

@article{Ishii2003Msx2AT,
  title={Msx2 and Twist cooperatively control the development of the neural crest-derived skeletogenic mesenchyme of the murine skull vault.},
  author={Mamoru Ishii and Amy E Merrill and Y Chan and Inna Gitelman and David P. C. Rice and Henry M Sucov and Robert E. Maxson},
  journal={Development},
  year={2003},
  volume={130 24},
  pages={6131-42}
}
The flat bones of the vertebrate skull vault develop from two migratory mesenchymal cell populations, the cranial neural crest and paraxial mesoderm. At the onset of skull vault development, these mesenchymal cells emigrate from their sites of origin to positions between the ectoderm and the developing cerebral hemispheres. There they combine, proliferate and differentiate along an osteogenic pathway. Anomalies in skull vault development are relatively common in humans. One such anomaly is… CONTINUE READING

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