Mst3b, a purine-sensitive Ste20-like protein kinase, regulates axon outgrowth.

  title={Mst3b, a purine-sensitive Ste20-like protein kinase, regulates axon outgrowth.},
  author={Nina Irwin and Yongmei Li and J E O'Toole and Larry Benowitz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={103 48},
The growth of axons is fundamental to the development and repair of brain circuitry. We show here that Mst3b, a neuron-specific homolog of the yeast kinase Ste20, is critical for axon outgrowth. Mst3b is activated in response to trophic factors, and suppressing its expression (via siRNAs) or its function (by a dominant-negative mutant) blocks axon outgrowth. Inosine, a purine nucleoside that stimulates axon outgrowth, activates Mst3b kinase activity, whereas 6-thioguanine, a purine analog that… CONTINUE READING


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