Msd1/SSX2IP-dependent microtubule anchorage ensures spindle orientation and primary cilia formation

@inproceedings{Hori2014Msd1SSX2IPdependentMA,
  title={Msd1/SSX2IP-dependent microtubule anchorage ensures spindle orientation and primary cilia formation},
  author={Akiko Hori and Chiho Ikebe and Masazumi Tada and Takashi Toda},
  booktitle={EMBO reports},
  year={2014}
}
Anchoring microtubules to the centrosome is critical for cell geometry and polarity, yet the molecular mechanism remains unknown. Here we show that the conserved human Msd1/SSX2IP is required for microtubule anchoring. hMsd1/SSX2IP is delivered to the centrosome in a centriolar satellite-dependent manner and binds the microtubule-nucleator γ-tubulin complex. hMsd1/SSX2IP depletion leads to disorganised interphase microtubules and misoriented mitotic spindles with reduced length and intensity… CONTINUE READING
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