Mrvil, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a lymphoid-restricted membrane protein Jaw1

@article{Shaughnessy1999MrvilAC,
  title={Mrvil, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a lymphoid-restricted membrane protein Jaw1},
  author={John D. Shaughnessy and David A. Largaespada and Erming Tian and Colin F. Fletcher and Brian C Cho and Paresh Vyas and Nancy A. Jenkins and Neal G. Copeland},
  journal={Oncogene},
  year={1999},
  volume={18},
  pages={2069-2084}
}
Ecotropic MuLVs induce myeloid leukemia in BXH2 mice by insertional mutagenesis of cellular proto-oncogenes or tumor suppressor genes. Disease genes can thus be identified by viral tagging as common sites of viral integration in BXH2 leukemias. Previous studies showed that a frequent common integration site in BXH2 leukemias is the Nf1 tumor suppressor gene. Unexpectedly, about half of the viral integrations at Nf1 represented a previously undiscovered defective nonecotropic virus, termed MRV… CONTINUE READING

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