MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion.

@article{Robas2003MrgX2IA,
  title={MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion.},
  author={Nicola M Robas and Emma Mead and Mark D Fidock},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 45},
  pages={44400-4}
}
MrgX2 is a recently identified orphan G-protein-coupled receptor whose ligand and physiological function were unknown. Here we describe cortistatin, a neuropeptide for which no specific receptor has been identified previously, as a high potency ligand at MrgX2. Cortistatin has several biological functions including roles in sleep regulation, locomotor activity, and cortical function. Using a "reverse pharmacology" approach, we have identified a number of additional cyclic peptide agonists for… CONTINUE READING
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