Mrf4 determines skeletal muscle identity in Myf5:Myod double-mutant mice

@article{KassarDuchossoy2004Mrf4DS,
  title={Mrf4 determines skeletal muscle identity in Myf5:Myod double-mutant mice},
  author={Lina Kassar-Duchossoy and Barbara Gayraud-Morel and Danielle Gom{\`e}s and Didier Rocancourt and M. Buckingham and Vasily Shinin and Shahragim Tajbakhsh},
  journal={Nature},
  year={2004},
  volume={431},
  pages={466-471}
}
In vertebrates, skeletal muscle is a model for the acquisition of cell fate from stem cells. Two determination factors of the basic helix–loop–helix myogenic regulatory factor (MRF) family, Myf5 and Myod, are thought to direct this transition because double-mutant mice totally lack skeletal muscle fibres and myoblasts. In the absence of these factors, progenitor cells remain multipotent and can change their fate. Gene targeting studies have revealed hierarchical relationships between these and… CONTINUE READING

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