MreB Actin-Mediated Segregation of a Specific Region of a Bacterial Chromosome

@article{Gitai2005MreBAS,
  title={MreB Actin-Mediated Segregation of a Specific Region of a Bacterial Chromosome},
  author={Zemer Gitai and Natalie Dye and Ann M. Reisenauer and Masaaki Wachi and Lawrence Shapiro},
  journal={Cell},
  year={2005},
  volume={120},
  pages={329-341}
}
Faithful chromosome segregation is an essential component of cell division in all organisms. The eukaryotic mitotic machinery uses the cytoskeleton to move specific chromosomal regions. To investigate the potential role of the actin-like MreB protein in bacterial chromosome segregation, we first demonstrate that MreB is the direct target of the small molecule A22. We then demonstrate that A22 completely blocks the movement of newly replicated loci near the origin of replication but has no… CONTINUE READING
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