Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis.

@article{Maser2001Mre11CA,
  title={Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis.},
  author={Richard S. Maser and Olga K. Mirzoeva and Julie M. Wells and Heidi A. Olivares and Bret R. Williams and Robert A. Zinkel and Peggy J. Farnham and John H.J Petrini},
  journal={Molecular and cellular biology},
  year={2001},
  volume={21 17},
  pages={6006-16}
}
We show that the Mre11 complex associates with E2F family members via the Nbs1 N terminus. This association and Nbs1 phosphorylation are correlated with S-phase checkpoint proficiency, whereas neither is sufficient individually for checkpoint activation. The Nbs1 E2F interaction occurred near the Epstein-Barr virus origin of replication as well as near a chromosomal replication origin in the c-myc promoter region and was restricted to S-phase cells. The Mre11 complex colocalized with PCNA at… CONTINUE READING