Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis.

  title={Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis.},
  author={Richard S. Maser and Olga K. Mirzoeva and Julie Wells and Heidi A. Olivares and Bret R. Williams and Robert A. Zinkel and Peggy J. Farnham and John H.J Petrini},
  journal={Molecular and cellular biology},
  volume={21 17},
We show that the Mre11 complex associates with E2F family members via the Nbs1 N terminus. This association and Nbs1 phosphorylation are correlated with S-phase checkpoint proficiency, whereas neither is sufficient individually for checkpoint activation. The Nbs1 E2F interaction occurred near the Epstein-Barr virus origin of replication as well as near a chromosomal replication origin in the c-myc promoter region and was restricted to S-phase cells. The Mre11 complex colocalized with PCNA at… CONTINUE READING
Highly Cited
This paper has 105 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-10 of 45 extracted citations

S-phase-coupled apoptosis in tumor suppression

Cellular and Molecular Life Sciences • 2011
View 4 Excerpts
Highly Influenced

DNA replication-dependent nuclear dynamics of the Mre11 complex.

Molecular cancer research : MCR • 2003
View 10 Excerpts
Highly Influenced

Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis

The Journal of experimental medicine • 2007
View 3 Excerpts
Highly Influenced

Functions of the adenovirus E4 proteins and their impact on viral vectors.

Frontiers in bioscience : a journal and virtual library • 2005
View 15 Excerpts
Highly Influenced

20 Years of Mre11 Biology: No End in Sight.

Molecular cell • 2018
View 2 Excerpts

106 Citations

Citations per Year
Semantic Scholar estimates that this publication has 106 citations based on the available data.

See our FAQ for additional information.