Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis.

@article{Maser2001Mre11CA,
  title={Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis.},
  author={Richard S. Maser and Olga K. Mirzoeva and Julie Wells and Heidi A. Olivares and Bret R. Williams and Robert A. Zinkel and Peggy J. Farnham and John H.J Petrini},
  journal={Molecular and cellular biology},
  year={2001},
  volume={21 17},
  pages={6006-16}
}
We show that the Mre11 complex associates with E2F family members via the Nbs1 N terminus. This association and Nbs1 phosphorylation are correlated with S-phase checkpoint proficiency, whereas neither is sufficient individually for checkpoint activation. The Nbs1 E2F interaction occurred near the Epstein-Barr virus origin of replication as well as near a chromosomal replication origin in the c-myc promoter region and was restricted to S-phase cells. The Mre11 complex colocalized with PCNA at… CONTINUE READING

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