Mre11-Rad50-Nbs complex is required to cap telomeres during Drosophila embryogenesis.

@article{Gao2009Mre11Rad50NbsCI,
  title={Mre11-Rad50-Nbs complex is required to cap telomeres during Drosophila embryogenesis.},
  author={Guanjun Gao and Xiaolin Bi and Jie Chen and Deepa Srikanta and Yikang S Rong},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 26},
  pages={10728-33}
}
Using Drosophila as a model system, we identified here a stringent requirement for Mre11-Rad50-Nbs (MRN) function in telomere protection during early embryonic development. Animals homozygous for hypomorphic mutations in either mre11 or nbs develop normally with minimal telomere dysfunction. However, they produce inviable embryos that succumb to failure of mitosis caused by covalent fusion of telomeric DNA. Interestingly, the molecular defect is not the absence of MRN interaction or of Mre11… CONTINUE READING

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