Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

  title={Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair},
  author={Robin S. B. Williams and Gabriel Moncali{\'a}n and Jessica S. Williams and Yoshiki Yamada and Oliver Limbo and David S. Shin and Lynda M. Groocock and Dana Cahill and Chiharu Hitomi and Grant Guenther and Davide Moiani and James P. Carney and Paul Russell and John A. Tainer},
Mre11 forms the core of the multifunctional Mre11-Rad50-Nbs1 (MRN) complex that detects DNA double-strand breaks (DSBs), activates the ATM checkpoint kinase, and initiates homologous recombination (HR) repair of DSBs. To define the roles of Mre11 in both DNA bridging and nucleolytic processing during initiation of DSB repair, we combined small-angle X-ray scattering (SAXS) and crystal structures of Pyrococcus furiosus Mre11 dimers bound to DNA with mutational analyses of fission yeast Mre11… CONTINUE READING
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