Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

@article{Williams2008Mre11DC,
  title={Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair},
  author={Robin S. B. Williams and Gabriel Moncali{\'a}n and Jessica S. Williams and Yoshiki Yamada and Oliver Limbo and David S. Shin and Lynda M. Groocock and Dana Cahill and Chiharu Hitomi and Grant Guenther and Davide Moiani and James P. Carney and Paul Russell and John A. Tainer},
  journal={Cell},
  year={2008},
  volume={135},
  pages={97-109}
}
Mre11 forms the core of the multifunctional Mre11-Rad50-Nbs1 (MRN) complex that detects DNA double-strand breaks (DSBs), activates the ATM checkpoint kinase, and initiates homologous recombination (HR) repair of DSBs. To define the roles of Mre11 in both DNA bridging and nucleolytic processing during initiation of DSB repair, we combined small-angle X-ray scattering (SAXS) and crystal structures of Pyrococcus furiosus Mre11 dimers bound to DNA with mutational analyses of fission yeast Mre11… CONTINUE READING
Highly Influential
This paper has highly influenced 31 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Highly Cited
This paper has 334 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 192 extracted citations

The Rad50 hook domain regulates DNA damage signaling and tumorigenesis.

Genes & development • 2014
View 4 Excerpts
Highly Influenced

Repair of double-strand breaks by end joining.

Cold Spring Harbor perspectives in biology • 2013
View 4 Excerpts
Highly Influenced

334 Citations

02040'10'13'16'19
Citations per Year
Semantic Scholar estimates that this publication has 334 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 57 references

Determination of the regularization parameter in indirecttransform methods using perceptual criteria

D. I. Svergun
J Appl Crystallogr • 1992
View 3 Excerpts
Highly Influenced