Mrd1p is required for processing of pre-rRNA and for maintenance of steady-state levels of 40 S ribosomal subunits in yeast.

@article{Jin2002Mrd1pIR,
  title={Mrd1p is required for processing of pre-rRNA and for maintenance of steady-state levels of 40 S ribosomal subunits in yeast.},
  author={Shao-bo Jin and Jian Zhao and Petra Bjork and Karin Schmekel and Per Olof Ljungdahl and Lars Wieslander},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 21},
  pages={18431-9}
}
Ribosome biogenesis is a conserved process in eukaryotes that requires a large number of small nucleolar RNAs and trans-acting proteins. The Saccharomyces cerevisiae MRD1 (multiple RNA-binding domain) gene encodes a novel protein that contains five consensus RNA-binding domains. Mrd1p is essential for viability. Mrd1p partially co-localizes with the nucleolar protein Nop1p. Depletion of Mrd1p leads to a selective reduction of 18 S rRNA and 40 S ribosomal subunits. Mrd1p associates with the 35 S… CONTINUE READING

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