Mpv17l protects against mitochondrial oxidative stress and apoptosis by activation of Omi/HtrA2 protease

  title={Mpv17l protects against mitochondrial oxidative stress and apoptosis by activation of Omi/HtrA2 protease},
  author={Stefanie Krick and Shaolin Shi and Wenjun Ju and Christian Faul and Su-Yi Tsai and Peter Mundel and Erwin P. B{\"o}ttinger},
  journal={Proceedings of the National Academy of Sciences},
  pages={14106 - 14111}
Cellular localization determines whether the serine protease HtrA2 exerts pro- or antiapoptotic functions. In contrast to the well-characterized proapoptotic function of cytosolic HtrA2, mechanisms underlying the mitochondrial protective role are poorly understood. Mpv17l is a transmembrane protein previously implicated in peroxisomal reactive oxygen species metabolism and a close homolog of the inner mitochondrial membrane protein Mpv17. Here we demonstrate a previously undescribed direct… 

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