MprAB is a stress-responsive two-component system that directly regulates expression of sigma factors SigB and SigE in Mycobacterium tuberculosis.

@article{He2006MprABIA,
  title={MprAB is a stress-responsive two-component system that directly regulates expression of sigma factors SigB and SigE in Mycobacterium tuberculosis.},
  author={Hongjun He and Raymond L. Hovey and Jason Kane and Vineet Singh and Thomas C. Zahrt},
  journal={Journal of bacteriology},
  year={2006},
  volume={188 6},
  pages={2134-43}
}
The genetic mechanisms mediating the adaptation of Mycobacterium tuberculosis within the host are poorly understood. The best-characterized regulatory systems in this organism include sigma factors and two-component signal transduction systems. mprAB is a two-component system required by M. tuberculosis for growth in vivo during the persistent stage of infection. In this report, we demonstrate that MprAB is stress responsive and regulates the expression of numerous stress-responsive genes in M… CONTINUE READING
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