Moxifloxacin inhibits cytokine-induced MAP kinase and NF-kappaB activation as well as nitric oxide synthesis in a human respiratory epithelial cell line.

@article{Werber2005MoxifloxacinIC,
  title={Moxifloxacin inhibits cytokine-induced MAP kinase and NF-kappaB activation as well as nitric oxide synthesis in a human respiratory epithelial cell line.},
  author={Sara Werber and Itamar Shalit and Ina Fabian and Guy Steuer and Taly Weiss and Hannah Blau},
  journal={The Journal of antimicrobial chemotherapy},
  year={2005},
  volume={55 3},
  pages={
          293-300
        }
}
BACKGROUND We previously demonstrated that the quinolone moxifloxacin prevents Candida albicans pneumonitis and epithelial nuclear factor kappaB (NF-kappaB) nuclear translocation in immunosuppressed mice. OBJECTIVES To explore the anti-inflammatory effects of moxifloxacin directly on a lung epithelial cell line. METHODS We studied the effect of clinically relevant concentrations of moxifloxacin (2.5-10 mg/L) on cytokine-induced activation of nitric oxide (NO) secretion, inducible NO… CONTINUE READING

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