Moving with or without will: functional neural correlates of alien hand syndrome

@article{Assal2007MovingWO,
  title={Moving with or without will: functional neural correlates of alien hand syndrome},
  author={Fr{\'e}d{\'e}ric Assal and Sophie Schwartz and Patrik Vuilleumier},
  journal={Annals of Neurology},
  year={2007},
  volume={62}
}
Alien hand syndrome is a rare neurological disorder in which movements are performed without conscious will. By using functional magnetic resonance imaging in a patient with alien hand syndrome after right parietal lesion, we could identify brain regions activated during involuntary or voluntary actions with the affected left hand. Alien hand movements involved a selective activation of contralateral primary motor cortex (M1), presumably released from conscious control by intentional planning… 
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TLDR
Evidence is provided for a distributed neural network associated with unwanted movements in alien hand syndrome, including brain regions known to be related to movement execution and planning as well as areas that have been linked to inhibition control and experience of agency.
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TLDR
In a functional MRI study of AHS, major activation was reported for the frontal inferior gyrus of the dominant hemisphere in voluntary movement of the affected hand, suggesting an important role of this area in organizing willed actions.
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TLDR
Her specific pattern of symptoms supports the role of the corpus callosum in interhemispheric communication for complex as well as fine motor activities and may indicate that it can serve as both an inhibitory and excitatory function depending on task demands.
Dominant posterior-variant alien hand syndrome after acute left parietal infarction
TLDR
A 57-year-old patient who developed symptoms of posterior AHS after an acute infarction in the left (presumably dominant) parietal lobe is described.
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TLDR
A general disturbance of veridical motor awareness and agency is suggested in this case of parietal AHS following right-hemisphere parietal damage, with left-sided somatosensory and proprioceptive impairment.
Alien Hand Syndrome
TLDR
The literature is reviewed to update advances in the understanding of the classification, pathophysiology, etiology, and treatment of Alien hand syndrome.
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TLDR
An 88-year-old right-handed male with involuntary movement of his left forearm and hand three hours prior to presentation is presented with Alien Hand Syndrome, which corresponded to findings on MRI of the brain, which showed acute infarcts of the right temporal lobe, right parietal cortex, andright parietal subcortex.
Selective Inhibition of Volitional Hand Movements after Stimulation of the Dorsoposterior Parietal Cortex in Humans
TLDR
Direct evidence is provided that a specific area in the dorsoposterior parietal cortex can inhibit volitional upper-limb responses with high selectivity in patients undergoing awake brain surgery.
Anarchic-hand syndrome: ERP reflections of lost control over the right hemisphere
TLDR
The neurophysiological results of the case G.H. who developed the syndrome after infarction of the left arteria pericallosa tend to support the split-brain account which assumes that the syndrome arises by the lack of communication between hemispheres that act according to their respective competences.
Controlling the alien hand through the mirror box. A single case study of Alien Hand Syndrome
TLDR
In one patient with right alien hand syndrome, the use of a mirror box paradigm improved motor speed and it is speculated that the visual feedback provided by the mirror increases the sense of congruence between intention and sensory feedback, leading to motor improvement.
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