Moving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytes

@article{Artemenko2014MovingTA,
  title={Moving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytes},
  author={Yulia Artemenko and Thomas J. Lampert and Peter N. Devreotes},
  journal={Cellular and Molecular Life Sciences},
  year={2014},
  volume={71},
  pages={3711-3747}
}
Chemotaxis, or directed migration of cells along a chemical gradient, is a highly coordinated process that involves gradient sensing, motility, and polarity. Most of our understanding of chemotaxis comes from studies of cells undergoing amoeboid-type migration, in particular the social amoeba Dictyostelium discoideum and leukocytes. In these amoeboid cells the molecular events leading to directed migration can be conceptually divided into four interacting networks: receptor/G protein, signal… CONTINUE READING

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Heterotrimeric G-protein shuttling via Gip1 extends the dynamic range of eukaryotic chemotaxis.

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Correction for Lampert et al., Shear force-based genetic screen reveals negative regulators of cell adhesion and protrusive activity.

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Proceedings of the National Academy of Sciences of the United States of America • 2018

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