Movement of the position of the transition state in protein folding.

@article{Matouschek1995MovementOT,
  title={Movement of the position of the transition state in protein folding.},
  author={Andreas Matouschek and Daniel E Otzen and Laura S. Itzhaki and Sophie E. Jackson and A. R. Fersht},
  journal={Biochemistry},
  year={1995},
  volume={34 41},
  pages={13656-62}
}
Hammond behavior, in which two neighboring states move closer to each other along the reaction coordinate as the energy difference between them becomes smaller, has previously been observed for the transition state of unfolding of barnase. Here, we report Hammond behavior for the small protein chymotrypsin inhibitor 2 (CI2), which folds and unfolds via a single rate-determining transition state and simple two-state kinetics. Mutants have been generated along the entire sequence of the protein… CONTINUE READING

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