Movement of the guide sequence during RNA catalysis by a group I ribozyme.

@article{Wang1993MovementOT,
  title={Movement of the guide sequence during RNA catalysis by a group I ribozyme.},
  author={Ju Fang Wang and William D Downs and Thomas R Cech},
  journal={Science},
  year={1993},
  volume={260 5107},
  pages={504-8}
}
Ribozymes derived from the self-splicing pre-ribosomal RNA of Tetrahymena act as sequence-specific endonucleases. The reaction involves binding an RNA or DNA substrate by base pairing to the internal guide sequence (IGS) to form helix P1. Site-specific photo-crosslinking localized the 5' end of the IGS in helix P1 to the vicinity of conserved bases between helices P4 and P5, supporting a major feature of the Michel-Westhof three-dimensional structure model. The crosslinked ribozyme retained… CONTINUE READING

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