Movement of replicating DNA through a stationary replisome.

  title={Movement of replicating DNA through a stationary replisome.},
  author={Katherine P. Lemon and Alan D Grossman},
  journal={Molecular cell},
  volume={6 6},
We found that DNA is replicated at a central stationary polymerase, and each replicated region moves away from the replisome. In Bacillus subtilis, DNA polymerase is predominantly located at or near midcell. When replication was blocked in a specific chromosomal region, that region was centrally located with DNA polymerase. Upon release of the block, each copy of the duplicated region was located toward opposite cell poles, away from the central replisome. In a roughly synchronous population of… CONTINUE READING


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