Movement of Bax from the Cytosol to Mitochondria during Apoptosis

  title={Movement of Bax from the Cytosol to Mitochondria during Apoptosis },
  author={Keith G. Wolter and Y T Hsu and Carolyn L. Smith and Amotz Nechushtan and Xu-Guang Xi and Richard J Youle},
  journal={The Journal of Cell Biology},
  pages={1281 - 1292}
Bax, a member of the Bcl-2 protein family, accelerates apoptosis by an unknown mechanism. Bax has been recently reported to be an integral membrane protein associated with organelles or bound to organelles by Bcl-2 or a soluble protein found in the cytosol. To explore Bcl-2 family member localization in living cells, the green fluorescent protein (GFP) was fused to the NH2 termini of Bax, Bcl-2, and Bcl-XL. Confocal microscopy performed on living Cos-7 kidney epithelial cells and L929… CONTINUE READING
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