Movement disorders induced in monkeys by chronic haloperidol treatment

  title={Movement disorders induced in monkeys by chronic haloperidol treatment},
  author={Bernard Weiss and Shirley Santelli and George Lusink},
After several months of treatment, Cebus apella, Cebus albifrons, and Saimiri sciurea monkeys maintained on haloperidol, in doses of 0.5 or 1.0 mg/kg orally 5 days per week, began to display severe movement disorders, typically 1–6 h post-drug. Cebus monkeys exhibited violent, uncontrolled movements that flung the animals about the cage. Such episodes usually lasted only a few minutes, recurring several times during the period following drug ingestion. Writhing and bizarre postures dominated… CONTINUE READING