Movement disorders associated with encephalitis lethargica: A video compilation

  title={Movement disorders associated with encephalitis lethargica: A video compilation},
  author={Joel A. Vilensky and Christopher G. Goetz and Sid Gilman},
  journal={Movement Disorders},
Encephalitis lethargica (EL; epidemic encephalitis; von Economo's disease) often presented with a movement disorder, and the motor consequences of postencephalitic parkinsonism (PEP) were characteristic of the chronic sequelae of this condition. PEP was similar to Parkinson's disease but was more variable and had some distinct features such as oculogyric crises. Although two previous publications have included video images of the movement disorders associated with EL and PEP, the sequences… 

Contemporary encephalitis lethargica presenting with agitated catatonia, stereotypy, and dystonia‐parkinsonism

  • R. DaleR. WebsterD. Gill
  • Medicine, Psychology
    Movement disorders : official journal of the Movement Disorder Society
  • 2007
Two recent cases of EL characterized by an acute encephalitis with mixed movement disorders and psychiatric disorders support the hypothesis that this syndrome is an inflammatoryEncephalitis that specifically effects dopamine neurotransmission.

Contemporary Encephalitis Lethargica: Phenotype, laboratory findings and treatment outcomes

It is suggested that in addition to anti-BG Abs FDG PET should be considered as a diagnostic tool for EL, and laboratory/imaging tests may lead to early initiation of immunomodulating and supporting therapies.

Hyperkinetic movement disorders associated with HIV and other viral infections.

On doing nothing: Descriptions of sleep, fatigue, and motivation in encephalitis lethargica

  • C. Ward
  • Psychology
    Movement disorders : official journal of the Movement Disorder Society
  • 2011
The study described here is based on a survey of clinical descriptions published in English, French, and German from 1917 to 1942 and its focus is on the history of clinical ideas, rather than applying modern pathophysiological concepts retrospectively.

Autoimmune Movement Disorders

A growing subset of immune-mediated movement disorders is the post-streptococcal neuropsychiatric disorders, some of which remain controversial and many of which still remain to be more clearly defined.

Focal Predominant Forms of Posthypoxic Action Myoclonus

Physicians should be aware of this limited phenotype of focal predominant postanoxic action myoclonus given that the unusual focal nature of the movements may result in incorrect diagnosis and treatment.

Movement Disorders in COVID-19: Whither Art Thou?

As neurologists working at a major academic medical center in the Bronx, a region that has been afflicted with an exceptionally high prevalence of COVID-19, they are impressed by the paucity of patients presenting with de novo movement disorders, both in the center and in the literature.

Myorhythmia: Phenomenology, etiology, and treatment

The clinical features that differentiate myorhythmia from other movement disorders are highlighted, focusing on the phenomenology, pathophysiology, and etiology of this poorly recognized movement disorder.

The Neuropsychiatric Consequences of Childhood Encephalitis: A Review of Cases from Middle-Eastern Countries

Although encephalitis may be an important cause of delirium and dementia as well as other psychopathology in childhood, those diagnoses present a diagnostic challenge to most child and adolescent psychiatrists leading to missed diagnoses.



Encephalitis lethargica syndrome: 20 new cases and evidence of basal ganglia autoimmunity.

Investigation found no evidence of viral encephalitis or other recognized causes of rapid-onset parkinsonism, and investigated the possibility that this phenotype could be a postinfectious autoimmune CNS disorder, and therefore similar to Sydenham's chorea.

Influenza RNA not Detected in Archival Brain Tissues from Acute Encephalitis Lethargica Cases or in Postencephalitic Parkinson Cases

It is unlikely that the 1918 influenza virus was neurotropic and directly responsible for the outbreak of EL, and reverse transcription-polymerase chain reaction for influenza matrix and nucleoprotein genes was negative in all cases.

Experimenting on the Past: The Enigma of von Economo's Encephalitis Lethargica

A review of the extensive literature by observers of the EL epidemic suggests that most contemporary clinicians, epidemiologists, and pathologists rejected the theory that the 1918 influenza virus was directly responsible for EL.

Chronic epidemic encephalitis

  • P. D.
  • Medicine
    Psychiatric Quarterly
  • 2005
The great variety of symptoms is easily understood when the authors recall that the virus can invade and occupy any area of the nervous system, and can therefore, cause pathological changes in the forebrain, mid-brain, hindbrain, cord or peripheral nerves.

The Denny‐brown collection: A research and teaching resource

A large collection of potentially valuable materials compiled by the late Dr Derek Denny‐Brown is described. This consists of 2,200 films of monkeys with central nervous system lesions, associated

Lack of detection of influenza genes in archived formalin-fixed, paraffin wax-embedded brain samples of encephalitis lethargica patients from 1916 to 1920.

It is concluded that influenza was not the causative agent of encephalitis lethargica or, possibly, that the virus had a hit-and-run mechanism and was no longer present in the brain at the time of death of the patients.